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JAX Frontend Platform

Knockout Mouse Project (KOMP)

Since 2006, scientists around the world have been working together to generate a targeted knockout mutation for every gene in the mouse genome.

The Knockout Mouse Project (KOMP) is providing critical tools for understanding gene function and the genetic causes of human diseases.

Coordinated by the International Mouse Phenotyping Consortium (IMPC), an international coalition will produce and phenotype a total of 5,000 knockout mice by 2016. The National Institutes of Health has funded three “KOMP2” centers in the United States, including one at The Jackson Laboratory, to work together on the immense task of producing and phenotyping these mice.  We are pleased to contribute to this international effort establishing a global resource of knockout mice and related database of gene function.

High throughput production

The KOMP Production Center draws upon our 80-plus years of experience delivering top-quality models in producing germline-competent chimeras and subsequent mouse cohorts.

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Phenotyping pipeline design

Broad phenotypic characterization of emerging mouse models will add important value and greatly enhance their utility to the scientific community.

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Faculty and Staff

Research Centers & Resources

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