Cre lines characterized by the JAX Cre Resource

The list of characterized Cre lines below is alphabetical by promoter.  FaceBase Resource strains and inducible Cre strains are at the bottom of the table.

The Jackson Laboratory Cre Repository uses the following LacZ Staining protocols:

JAX Cre Repository LacZ Staining

Stock number(links to data sheet) Strain name
(links to expression data)
Promoter (species) Expected site of expression Expression data thumbnail
006149 B6.Cg-Tg(ACTA1-cre)79Jme/J ACTA1 (human)

Cre activity is restricted to adult striated muscle fibers and embryonic striated muscle cells of the somites and heart.

ACTA1 slideACTA1 image
010803 B6;FVB-Tg(Adipoq-cre)1Evdr/J Adipoq, adiponectin, C1Q and collagen domain containing (mouse) Cre recombinase activity is expected in white adipose tissue (WAT) and brown adipose tissue (BAT) Adipoq-cre Characterization
012899 STOCK Agrp<tm1(cre)Lowl>/J Agrp (mouse)

ArGP neurons in the hypothalamus

Agrp pons med
003574 B6.Cg-Tg(Alb-cre)21Mgn/J Alb, albumin (rat) Cre recombinase expression is expected in the Liver Alb-cre
016832 B6.FVB(129)-Tg(Alb1-cre)1Dlr/J Alb1, albumin (mouse) Cre recombinase expression is expected in the Liver Alb1-cre Characterization
007915 129S.FVB-Tg(Amh-cre)8815Reb/J Amh (mouse)

Testis Sertoli cell-specific promoter elements of the anti-Mullerian hormone (Amh) gene

Amh-cre slide
006881 B6.Cg-Tg(Aqp2-cre)1Dek/J Aqp2 (mouse)

Transgenic cre activity, directed by the mouse aquaporin 2 promoter, is observed in kidney cells (collecting duct, left) and testes (sperm, right).

Aqp2 kidneyAqp2 testes
010774 B6(Cg)-Calb2<tm1(cre)Zjh>/J Calb2, calbindin 2 Cre activity is expected in calretinin interneurons in the brain and cortex driven by the endogenous Calb2 promoter/enhancer elements Calb2-cre Characterization
005359

B6.Cg-Tg(Camk2a-cre)T29-1Stl/J

Camk2a, calcium/calmodulin-dependent protein kinase II alpha (mouse)

Cre recombinase expression is expected in the forebrain, specifically the CA1 pyramidal cell layer in the hippocampus Camk2a-cre
012706 STOCK Cck<tm1.1(cre)Zjh>/J Cck, cholecystokinin (mouse) Cre recombinase activity is expected in cholecystokinin positive neurons (interneurons) of the cortex. 

Expression also seen in Adult spinal cord and embryonic day 15.5 spinal cord and heart (bottom left and right).

Cck-cre CharacterizationCck cre E15Cck thoracic spie
008520 B6.Cg-Tg(CD2-cre)4Kio/J CD2, CD2 molecule (human) Cre recombinase activity is expected in T cells and B cells (all committed B cell and T cell progenitors) CD2-cre Characterization
004126 C.Cg-Cd19<tm1(cre)Cgn> Ighb/J Cd19 Cre recombinase expression is expected in B cells Cd19-cre Characterization
006137

B6.Cg-Tg(Cdh5-cre)7Mlia/J

Cdh5, cadherin 5

Embryonic and adult cre recombinase activity is reported in endothelium of developing and quiescent vessels of all organs examined, as well as within a subset of hematopoietic cells

Cdh5-cre
012237 B6.Cg-Tg(Cdh16-cre)91Igr/J Chd16 (mouse)

In the adult mouse expression is limited to the renal tubules especially the collecting ducts, loops of Henle and distal tubules.

Cdh16-cre slide
006410 B6;129S6-Chat<tm1(cre)Lowl>/J Chat, choline acetyltransferase (mouse) Cre recombinase activity is reported in all cholinergic neurons Chat-cre
010910 STOCK Cort<tm1(cre)Zjh>/J Cort, cortistatin Cre recombinase expression is expected in Cort-expressing cells (CST positive neurons) Cort-cre Expression Data
012704 B6(Cg)-Crh<tm1(cre)Zjh>/J Crh, corticotropin releasing hormone Cre recombinase activity is expected in CRH positive neurons Crh-cre Characterization
008839 B6;C3-Tg(Cyp39a1-cre)1Aibs/J Cyp39a1, cytochrome P450, family 39, subfamily a, polypeptide 1 (mouse) Cre recombinase expression is directed to cerebral cortex, hippocampus, striatum, olfactory bulb, and cerebellum Cyp39a1-cre Characterization
008199 STOCK Tg(dlx6a-cre)1Mekk/J dlx6a, distal-less homeobox gene 6a Cre recombinase activity is expected in GABAergic forebrain neurons dlx6a-cre Characterization
003314 FVB/N-Tg(EIIa-cre)C5379Lmgd/J Ella, adenovirus (adenovirus) Cre recombinase activity is expected in a wide range of tissues, including the germ cells that transmit the genetic alteration to progeny FVB/EIIA-cre Characterization
005628

B6.129S2-Emx1<tm1(cre)Krj>/J

Emx1, empty spiracles homolog 1 (Drosophila)

Cre recombinase activity is reported in neurons of the neocortex and hippocampus, and in the glial cells of the pallium, mimicking the pattern of expression of the endogenous gene

Emx1-cre Characterization
007916 STOCK En1<tm2(cre)Wrst>/J En1, engrailed 1 Cre recombinase activity is expected in spinal cord V1 interneurons, the embryonic mesencephalon and rhombomere 1 by E9, as well as in the ventral ectoderm of the limbs, in a subset of somite cells, and some mesoderm-derived tissues. En1-cre Characterization Data
005069 B6.Cg-Tg(Fabp4-cre)1Rev/J Fabp4, fatty acid binding protein 4 Cre recombinase activity is reported in brown and white adipose tissue. Fabp4-cre Characterization Data
010802 STOCK Gad2<tm2(cre)Zjh>/J Gad2, glutamic acid decarboxylase 2 Cre recombinase activity is expected in Gad2 positive neurons Gad2-cre Expression Data
004600 FVB-Tg(GFAP-cre)25Mes/J GFAP, glial fibrillary acidic protein (human) Cre recombinase activity is reported in the central nervous system, affecting astrocytes, oligodendroglia, ependyma and some neurons; also periportal cells of the liver Gfap-cre Adult Brain
012887 B6.Cg-Tg(Gfap-cre)77.6Mvs/J Gfap (mouse)

Cre recombinase activity is targeted to most astrocytes throughout the healthy brain and spinal cord and to essentially all astrocytes after Central Nervous System (CNS) injury. Cre recombinase activity is also targeted to a subpopulation of the adult stems in the subventricular zone.

Gfap whole brain
006474 C57BL/6-Tg(Grik4-cre)G32-4Stl/J

Grik4, glutamate receptor, ionotropic, kainate 4 (mouse)

Cre recombinase activity is reported at 14 days old in area CA3 of the hippocampus, and at 8 weeks of age, recombination is observed in nearly 100% of pyramidal cells in area CA3; recombination is also observed in other brain areas, but at distinctly lower frequencies

Grik4-cre
008870 C57BL/6-Tg(Hspa2-cre)1Eddy/J Hspa2, heat shock protein 2 (mouse) Cre recombination is expected to occur in leptotene/zygotene spermatocytes Hspa2-cre Characterization Data
003573 B6.Cg-Tg(Ins2-cre)25Mgn/J Ins2, insulin 2 (rat) Cre recombinase activity is expected in pancreatic beta cells, as well as the hypothalamus Ins2-cre Characterization
008068 B6.Cg-Tg(Itgax-cre)1-1Reiz/J Itgax, integrin alpha X (mouse) Cre recombinase activity is expected in CD8-, CD8+ dendritic cells, tissue derived dendritic cells from lymph nodes, lung and epidermis and plasmacytoid dendritic cells Itgax-cre Characterization
004782 STOCK Tg(KRT14-cre)1Amc/J KRT14, keratin 14 (human) Cre recombinase activity is reported in skin, the oral ectoderm including the dental lamina at 11.75 d.p.c., and the dental epithelium by 14.5 d.p.c. Krt14-cre
003802 B6.Cg-Tg(Lck-cre)548Jxm/J Lck, lymphocyte protein tyrosine kinase (mouse) Cre recombinase activity is reported in thymocytes Lck-cre Characterization
012837 B6.Cg-Tg(Lck-cre)3779Nik/J Lck (mouse)

These mice are useful for studying the consequences of mutations induced after positive selection in the thymus.

Lck cre P56 thymus
008320 B6.129-Lepr<tm2(cre)Rck>/J Lepr (mouse)

Cre activity is demonstrable in the hypothalamus (arcuate, dorsomedial, lateral, and ventromedial nuclei), limbic and cortical brain regions (basolateral amygdaloid nucleus, piriform cortex, and lateral entorhinal cortex), and retrosplenial cortex.

Lepr adult brain
004781 B6.129P2-Lyz2<tm1(cre)Ifo>/J Lyz2, Lysozyme 2 (mouse) Cre recombinase activity is reported in myeloid cells, including monocytes, mature macrophages and granulocytes Lyz2-cre P7 Heart
006600 B6.129S1-Mnx1<tm4(cre)Tmj>/J Mnx1, motor neuron and pancreas homeobox 1 (mouse) Cre recombinase activity is reported in motor neurons Mnx1-cre Adult Pancreas
007893 B6.129S4-Myf5<tm3(cre)Sor>/J Myf5, myogenic factor 5 Cre recombinase activity is expected in skeletal muscle and the dermis, and in several ectopic locations Myf5-cre Characterization
011038 B6.FVB-Tg(Myh6-cre)2182Mds/J Myh6 (mouse)

Cardiac tissue

Myc cardiac tissue
003771 B6.Cg-Tg(Nes-cre)1kln/J Nes, nestin (rat) Cre recombinase activity is reported in the central and peripheral nervous system and a few isolated kidney and heart cells Nes-cre Characterization
006333 B6.FVB(Cg)-Tg(Neurog3-cre)C1Able/J Neurog3, neurogenin 3, (rat) Cre recombinase activity is expected in islets of the adult pancreas, small intestine enteroendocrine cells, endocrine portions of the stomach, all pancreatic endocrine cells, and in some non-endocrine intestinal cells Neurog3-cre Characterization Data
008661 C57BL/6J-Tg(Nkx2-1-cre)2Sand/J Nkx2-1 Cre recombinase activity is directed to brain interneuron progenitors, developing lung, thyroid, and pituitary by the Nkx2.1 promoter/enhancer regions Nkx2-cre Characterization
008205 B6.Cg-Tg(NPHS2-cre)295Lbh/J NPHS2 (human)

Cre-recombinase activity is reported in podocytes during late capillary loop stage of glomerular development and persists in podocytes of mature glomeruli

NPHS2-cre kidney P56
006364 FVB-Tg(Nr5a1-cre)2Lowl/J Nr5a1, Nuclear receptor subfamily 5 group A member 1 (mouse) Cre recombinase activity is reported in Ventromedial Hypothalamus, Cortex, Adrenal Gland, Pituitary Gland and Gonads  Nr5a1-cre Adult Ovary
006668 B6;129P2-Omp<tm4(cre)Mom>/MomJ Omp, Olfactory Marker Protein (mouse) Cre recombinase activity is reported in mature olfactory sensory neurons Omp-cre Adult Brain
005549 B6;129-Pax3<tm1(cre)Joe>/J Pax3, paired box gene 3 Cre recombinase activity is expected in the dorsal neural tube and somites of E9 to 11.5 embryos and in the cardiac neural crest cells and colonic epithelia of E11.5 embryos Pax3-cre Characterization Data
008535 C57BL/6-Tg(Pf4-cre)Q3Rsko/J Pf4, platelet factor 4 (mouse) Cre activity is expected in the majority of megakaryocytes Pf4-cre Characterization
005965

STOCK Tg(Pomc1-cre)16Lowl/J

Pomc1 (mouse) Cre recombinase activity is reported in POMC neurons in the arcuate nucleus of the hypothalamus and scattered  in the dentate gyrus of the hippocampus Pomc1-cre Characterization
008069 B6;129P2-Pvalb<tm1(cre)Arbr>/J Pvalb, parvalbumin Cre activity is expected in neurons that express parvalbumin, such as interneurons in the brain and proprioceptive afferent sensory neurons in the dorsal root ganglia Pvalb-cre Characterization
009613 B6;C3-Tg(Scnn1a-cre)3Aibs/J Scnn1a (mouse)

Cre expression directed to cortex, thalamus, midbrain, and cerebellum.

Scnn1a p56 brainScnn1a lung
005622 B6.Cg-Shh<tm1(EGFP/cre)Cjt>/J Shh, sonic hedgehog Cre activity is expected to follow endogenous Shh expression patterns ShhEGFP-cre Characterization
006395

STOCK Tg(Sim1-cre)1Lowl/J

Sim1, single-minded homolog 1 (Drosophila)(mouse) Cre recombinase activity is expected in all areas that endogenously express Sim1, including paraventricular hypothalamus and other parts of the brain Sim1-cre
006660 B6.SJL-Slc6a3<tm1.1(cre)Bkmn>/J Slc6a3, solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 Cre recombinase activity is expected in dopaminergic cell groups (substantia nigra (SN) and ventral tegmental area (VTA), as well as in the retrorubral field) Slc6a3-cre Characterization
013044 STOCK Sst<tm2.1(cre)Zjh>/J Sst, somatostatin Cre recombinase activity is expected in somatostatin positive neurons (including dendritic inhibitory interneurons such as Martinotti cells and Oriens-Lacunosum-Moleculare cells) Sst-cre Characterization
008208 STOCK Tg(Stra8-cre)1Reb/J Stra8 (mouse)

Stra8-cre transgenic mice may be useful in generating conditional knockouts in postnatal, premeiotic, male germ cells for studying spermatogenesis.

Stra8 p56 testiStra8 high expression p56 testi
003966 B6.Cg-Tg(Syn1-cre)671Jxm/J Syn1 (rat)

Cre recombinase activity is detected in neuronal cells, including brain, spinal cord and DRGs, as early as E12.5, as well as in neurons in adult.

syn1 brain image
004746 STOCK Tg(Tagln-cre)1Her/J Tagln, transgelin (mouse) Cre recombinase activity is expected in smooth muscle Tagln-cre Characterization
006878 B6.129S6-Tagln<tm2(cre)Yec>/J Tagln (mouse)

Cre recombinase activity is shown in adult smooth muscle cells (such as arteries, veins, and visceral organs) and cardiac myocytes, but activity is not observed in the same embryonic tissues.

Tagln cre heart
006143 FVB/N-Tg(Thy1-cre)1Vln/J Thy1 (mouse) Cre recombinase activity is expected in neurons of the cortex and hippocampus Thy1-cre Characterization
008712 B6.129X1-Twist2<tm1.1(cre)Dor>/J Twist2, twist basic helix-loop-helix transcription factor 2 Cre recombinase activity is expected in mesoderm as early as embryonic day 9.5, in mesodermal tissues such as branchial arches and somites, and in condensed mesenchyme-derived chondrocytes and osteoblasts. Twist2-cre Characterization
008610 B6.Cg-Tg(Vav1-cre)A2Kio/J Vav1 (mouse)

Using crosses to a reporter strain, variegated germline (testis and ovaries), and heart and gut expression is also reported. When bred with mice containing a loxP-flanked sequence of interest, Cre-mediated recombination will result in deletion of the floxed sequence(s) in the offspring. These Vav1-Cre transgenic mice may be useful for generating conditional mutations in hematopoietic cells.

Vav1 adult spleen
004586 B6.SJL-Tg(Vil-cre)997Gum/J Vil1, villin 1 (mouse) Cre recombinase activity is expected in villi and crypts of the small and large intestine Villin-cre Characterization
010908 STOCK Vip<tm1(cre)Zjh>/J Vip, vasoactive intestinal polypeptide Cre recombinase activity has been reported in some GABAergic interneurons Vip-cre Characterization
009107 B6.Cg-Tg(Wnt1-cre)11Rth Tg(Wnt1-GAL4)11Rth/J Wnt1, wingless-related MMTV integration site 1 (mouse Cre recombinase activity is expected in embryonic neural tube, midbrain, dorsal and ventral midlines of the midbrain and caudal diencephalon, the mid-hindbrain junction and dorsal spinal cord Wnt1-cre Characterization

Facebase Tools Cre Strains:
_________________________________________________________

Stock number(links to data sheet) Strain name
(links to expression data)
Promoter (species) Expected site of expression Expression data thumbnail
018151 C57BL/6N-Krt17<tm1(cre,Cerulean)Murr>/GrsrJ Krt17, keratin 17 (mouse) Cre recombinase expression is driven by the endogenous keratin 17 (Krt17) promoter/enhancer elements Krt17-cre Craniofacial Characterization
009388 B6;129S1-Osr2<tm2(cre)Jian>/J Osr2, odd-skipped related 2 (Drosophila), mouse, laboratory Cre recombinase activity is reported in developing palate and urogenital tract Osr2-cre Craniofacial Characterization
018791 C57BL/6J-Tg(Trp63,-cre,-Cerulean)3Grsr/GrsrJ Trp63, transformation related protein 63 (mouse) Cre recombinase expression is driven by Trp63 promoter/enhancer elements p63-cre Craniofacial Characterization
018792 C57BL/6J-Tg(Trp63,-cre,-Cerulean)4Grsr/GrsrJ Trp63, transformation related protein 63 (mouse) Cre recombinase expression is driven by Trp63 promoter/enhancer elements p63-cre Craniofacial Characterization
005584 B6.Cg-Tg(Prrx1-cre)1Cjt/J Prrx1, paired related homeobox 1 (rat) Cre recombinase activity is expected in early limb bud mesenchyme and in a subset of craniofacial mesenchyme, along with limited female germline expression Prrx1-cre Craniofacial Characterization
018754 C57BL/6J-Tg(Tbx22,-cre,-mCherry)1Grsr/GrsrJ Tbx22, T-box transcription factor 22 (mouse) Cre recombinase expression is driven by Tbx22 promoter/enhancer elements Tbx22-cre Craniofacial Characterization
012719 STOCK Tgfb3<tm1(cre)Vk/J

Tgfb3, transforming growth factor, beta 3 (mouse) 

Cre recombinase activity is expected in the heart, pharyngeal arches, otic vesicle, mid brain, limb buds, midline palatal epithelium, and whisker follicles during embryo and fetus development Tgfb3-cre Craniofacial Characterization
009107 B6.Cg-Tg(Wnt1-GAL4)11Rth Tg(Wnt1-Cre)11Rth

Wnt1, wingless-related MMTV integration site 1 (mouse)

Cre recombinase activity is expected in embryonic neural tube, midbrain, caudal diencephalon, the mid-hindbrain junction, dorsal spinal cord, and neural crest cells B6.Wnt1-cre Craniofacial Characterization

Inducible Strains:
_________________________________________________________

Stock number(links to data sheet) Strain name
(links to expression data)
Promoter (species) Expected site of expression Expression data thumbnail
004682 B6.Cg-Tg(CAG-cre/Esr1)5Amc/J ACTB, actin, beta (chicken) Tamoxifen-inducible Cre recombinase expression is expected in most tissue types Cag-cre/Esr1 Characterization
006774 FVB-Tg(Col2a1-cre/ERT)KA3Smac/J Col2a1, collagen, type II, alpha 1 (mouse) Tamoxifen-inducible cre expression is expected in cells of the chondrogenic lineage (cartilage) during embryogenesis and postnatally. Col2a1-cre Characterization Data
010705 B6(Cg)-Dlx5<tm1(cre/ERT2)Zjh>/J Dlx5, distal-less homeobox 5 Tamoxifen-inducible Cre recombinase activity is expected in the cortex Dlx5-cre/ERT2 Characterization
005107 STOCK Tg(KRT14-cre/ERT)20Efu/J KRT14, keratin 14 (human) Tamoxifen-inducible Cre recombinase expression is expected in keratinocytes KRT14-cre/ERT Characterization
008875 B6.129P2-Lgr5<tm1(cre/ERT2)Cle>/J Lgr5, leucine rich repeat containing G protein coupled receptor 5 Tamoxifen-inducible Cre recombinase expression is expected in crypt base columnar cells in small intestine (stem cells of the small intestine) and colon Lgr5-cre/ERT2 Characterization
005657 B6.FVB(129)-Tg(Myh6-cre/Esr1)1Jmk/J Myh6, myosin, heavy polypeptide 6,(mouse) Tamoxifen-inducible Cre recombinase expression is expected in developing and adult heart Myh6-cre/Esr1 Characterization
005975 B6.Cg-Tg(Plp1-cre/ERT)3Pop/J  Plp1, proteolipid protein (myelin) 1 (mouse) Tamoxifen-inducible Cre recombinase expression is expected in oligodendrocytes and Schwann cells Plp1-cre/ERT Characterization
008085 B6.Cg-Tg(UBC-cre/ERT2)1Ejb/J UBC, ubiquitin C (human) Tamoxifen-inducible Cre recombinase expression is expected in all tissue types UBC-cre/ERT2 Characterization Data
009103 B6;C3-Tg(Wfs1-cre/ERT2)3Aibs/J Wfs1, Wolfram syndrome 1 homolog (human) Tamoxifen-inducible Cre recombinase expression is directed to cortex, hippocampus, striatum, thalamus and cerebellum only following tamoxifen administration Wfs1-cre/ERT2 Characterization Data