Cre lines characterized by the JAX Cre Resource
The Jackson Laboratory Cre Repository uses the following LacZ Staining protocols:
JAX Cre Repository LacZ Staining
| Stock number(links to data sheet) | Strain name (links to expression data) |
Promoter (species) | Expected site of expression | Expression data thumbnail |
| 010803 | B6;FVB-Tg(Adipoq-cre)1Evdr/J | Adipoq, adiponectin, C1Q and collagen domain containing (mouse) | Cre recombinase activity is expected in white adipose tissue (WAT) and brown adipose tissue (BAT) |  |
| 003574 | B6.Cg-Tg(Alb-cre)21Mgn/J | Alb, albumin (rat) | Cre recombinase expression is expected in the Liver |  |
| 016832 | B6.FVB(129)-Tg(Alb1-cre)1Dlr/J | Alb1, albumin (mouse) | Cre recombinase expression is expected in the Liver |  |
| 010774 | B6(Cg)-Calb2<tm1(cre)Zjh>/J | Calb2, calbindin 2 | Cre activity is expected in calretinin interneurons in the brain and cortex driven by the endogenous Calb2 promoter/enhancer elements |  |
| 005359 |
Camk2a, calcium/calmodulin-dependent protein kinase II alpha (mouse) |
Cre recombinase expression is expected in the forebrain, specifically the CA1 pyramidal cell layer in the hippocampus |  | |
| 012706 | STOCK Cck<tm1.1(cre)Zjh>/J | Cck, cholecystokinin | Cre recombinase activity is expected in cholecystokinin positive neurons (interneurons) of the cortex |  |
| 008520 | B6.Cg-Tg(CD2-cre)4Kio/J | CD2, CD2 molecule (human) | Cre recombinase activity is expected in T cells and B cells (all committed B cell and T cell progenitors) |  |
| 004126 | C.Cg-Cd19<tm1(cre)Cgn> Ighb/J | Cd19 | Cre recombinase expression is expected in B cells |  |
| 006137 |
Cdh5, cadherin 5 |
Embryonic and adult cre recombinase activity is reported in endothelium of developing and quiescent vessels of all organs examined, as well as within a subset of hematopoietic cells |
 | |
| 006410 | B6;129S6-Chat<tm1(cre)Lowl>/J | Chat, choline acetyltransferase (mouse) | Cre recombinase activity is reported in all cholinergic neurons |  |
| 010910 | STOCK Cort<tm1(cre)Zjh>/J | Cort, cortistatin | Cre recombinase expression is expected in Cort-expressing cells (CST positive neurons) |  |
| 012704 | B6(Cg)-Crh<tm1(cre)Zjh>/J | Crh, corticotropin releasing hormone | Cre recombinase activity is expected in CRH positive neurons |  |
| 008839 | B6;C3-Tg(Cyp39a1-cre)1Aibs/J | Cyp39a1, cytochrome P450, family 39, subfamily a, polypeptide 1 (mouse) | Cre recombinase expression is directed to cerebral cortex, hippocampus, striatum, olfactory bulb, and cerebellum |  |
| 008199 | STOCK Tg(dlx6a-cre)1Mekk/J | dlx6a, distal-less homeobox gene 6a | Cre recombinase activity is expected in GABAergic forebrain neurons |  |
| 003314 | FVB/N-Tg(EIIa-cre)C5379Lmgd/J | Ella, adenovirus (adenovirus) | Cre recombinase activity is expected in a wide range of tissues, including the germ cells that transmit the genetic alteration to progeny |  |
| 005628 |
Emx1, empty spiracles homolog 1 (Drosophila) |
Cre recombinase activity is reported in neurons of the neocortex and hippocampus, and in the glial cells of the pallium, mimicking the pattern of expression of the endogenous gene |
 | |
| 007916 | STOCK En1<tm2(cre)Wrst>/J | En1, engrailed 1 | Cre recombinase activity is expected in spinal cord V1 interneurons, the embryonic mesencephalon and rhombomere 1 by E9, as well as in the ventral ectoderm of the limbs, in a subset of somite cells, and some mesoderm-derived tissues. |  |
| 005069 | B6.Cg-Tg(Fabp4-cre)1Rev/J | Fabp4, fatty acid binding protein 4 | Cre recombinase activity is reported in brown and white adipose tissue. |  |
| 010802 | STOCK Gad2<tm2(cre)Zjh>/J | Gad2, glutamic acid decarboxylase 2 | Cre recombinase activity is expected in Gad2 positive neurons |  |
| 004600 | FVB-Tg(GFAP-cre)25Mes/J | GFAP, glial fibrillary acidic protein (human) | Cre recombinase activity is reported in the central nervous system, affecting astrocytes, oligodendroglia, ependyma and some neurons; also periportal cells of the liver |  |
| 006474 | C57BL/6-Tg(Grik4-cre)G32-4Stl/J |
Grik4, glutamate receptor, ionotropic, kainate 4 (mouse) |
Cre recombinase activity is reported at 14 days old in area CA3 of the hippocampus, and at 8 weeks of age, recombination is observed in nearly 100% of pyramidal cells in area CA3; recombination is also observed in other brain areas, but at distinctly lower frequencies |
 |
| 008870 | C57BL/6-Tg(Hspa2-cre)1Eddy/J | Hspa2, heat shock protein 2 (mouse) | Cre recombination is expected to occur in leptotene/zygotene spermatocytes |  |
| 003573 | B6.Cg-Tg(Ins2-cre)25Mgn/J | Ins2, insulin 2 (rat) | Cre recombinase activity is expected in pancreatic beta cells, as well as the hypothalamus |  |
| 008068 | B6.Cg-Tg(Itgax-cre)1-1Reiz/J | Itgax, integrin alpha X (mouse) | Cre recombinase activity is expected in CD8-, CD8+ dendritic cells, tissue derived dendritic cells from lymph nodes, lung and epidermis and plasmacytoid dendritic cells |  |
| 004782 | STOCK Tg(KRT14-cre)1Amc/J | KRT14, keratin 14 (human) | Cre recombinase activity is reported in skin, the oral ectoderm including the dental lamina at 11.75 d.p.c., and the dental epithelium by 14.5 d.p.c. |  |
| 003802 | B6.Cg-Tg(Lck-cre)548Jxm/J | Lck, lymphocyte protein tyrosine kinase (mouse) | Cre recombinase activity is reported in thymocytes |  |
| 004781 | B6.129P2-Lyz2<tm1(cre)Ifo>/J | Lyz2, Lysozyme 2 (mouse) | Cre recombinase activity is reported in myeloid cells, including monocytes, mature macrophages and granulocytes |  |
| 006600 | B6.129S1-Mnx1<tm4(cre)Tmj>/J | Mnx1, motor neuron and pancreas homeobox 1 (mouse) | Cre recombinase activity is reported in motor neurons |  |
| 007893 | B6.129S4-Myf5<tm3(cre)Sor>/J | Myf5, myogenic factor 5 | Cre recombinase activity is expected in skeletal muscle and the dermis, and in several ectopic locations |  |
| 003771 | B6.Cg-Tg(Nes-cre)1kln/J | Nes, nestin (rat) | Cre recombinase activity is reported in the central and peripheral nervous system and a few isolated kidney and heart cells |  |
| 006333 | B6.FVB(Cg)-Tg(Neurog3-cre)C1Able/J | Neurog3, neurogenin 3, (rat) | Cre recombinase activity is expected in islets of the adult pancreas, small intestine enteroendocrine cells, endocrine portions of the stomach, all pancreatic endocrine cells, and in some non-endocrine intestinal cells |  |
| 008661 | C57BL/6J-Tg(Nkx2-1-cre)2Sand/J | Nkx2-1 | Cre recombinase activity is directed to brain interneuron progenitors, developing lung, thyroid, and pituitary by the Nkx2.1 promoter/enhancer regions |  |
| 006364 | FVB-Tg(Nr5a1-cre)2Lowl/J | Nr5a1, Nuclear receptor subfamily 5 group A member 1 (mouse) | Cre recombinase activity is reported in Ventromedial Hypothalamus, Cortex, Adrenal Gland, Pituitary Gland and Gonads |  |
| 006668 | B6;129P2-Omp<tm4(cre)Mom>/MomJ | Omp, Olfactory Marker Protein (mouse) | Cre recombinase activity is reported in mature olfactory sensory neurons |  |
| 005549 | B6;129-Pax3<tm1(cre)Joe>/J | Pax3, paired box gene 3 | Cre recombinase activity is expected in the dorsal neural tube and somites of E9 to 11.5 embryos and in the cardiac neural crest cells and colonic epithelia of E11.5 embryos |  |
| 008535 | C57BL/6-Tg(Pf4-cre)Q3Rsko/J | Pf4, platelet factor 4 (mouse) | Cre activity is expected in the majority of megakaryocytes |  |
| 005965 | Pomc1 (mouse) | Cre recombinase activity is reported in POMC neurons in the arcuate nucleus of the hypothalamus and scattered in the dentate gyrus of the hippocampus |  | |
| 008069 | B6;129P2-Pvalb<tm1(cre)Arbr>/J | Pvalb, parvalbumin | Cre activity is expected in neurons that express parvalbumin, such as interneurons in the brain and proprioceptive afferent sensory neurons in the dorsal root ganglia |  |
| 005622 | B6.Cg-Shh<tm1(EGFP/cre)Cjt>/J | Shh, sonic hedgehog | Cre activity is expected to follow endogenous Shh expression patterns |  |
| 006395 | Sim1, single-minded homolog 1 (Drosophila)(mouse) | Cre recombinase activity is expected in all areas that endogenously express Sim1, including paraventricular hypothalamus and other parts of the brain |  | |
| 006660 | B6.SJL-Slc6a3<tm1.1(cre)Bkmn>/J | Slc6a3, solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 | Cre recombinase activity is expected in dopaminergic cell groups (substantia nigra (SN) and ventral tegmental area (VTA), as well as in the retrorubral field) |  |
| 013044 | STOCK Sst<tm2.1(cre)Zjh>/J | Sst, somatostatin | Cre recombinase activity is expected in somatostatin positive neurons (including dendritic inhibitory interneurons such as Martinotti cells and Oriens-Lacunosum-Moleculare cells) |  |
| 004746 | STOCK Tg(Tagln-cre)1Her/J | Tagln, transgelin (mouse) | Cre recombinase activity is expected in smooth muscle |  |
| 006143 | FVB/N-Tg(Thy1-cre)1Vln/J | Thy1 (mouse) | Cre recombinase activity is expected in neurons of the cortex and hippocampus |  |
| 008712 | B6.129X1-Twist2<tm1.1(cre)Dor>/J | Twist2, twist basic helix-loop-helix transcription factor 2 | Cre recombinase activity is expected in mesoderm as early as embryonic day 9.5, in mesodermal tissues such as branchial arches and somites, and in condensed mesenchyme-derived chondrocytes and osteoblasts. |  |
| 004586 | B6.SJL-Tg(Vil-cre)997Gum/J | Vil1, villin 1 (mouse) | Cre recombinase activity is expected in villi and crypts of the small and large intestine |  |
| 010908 | STOCK Vip<tm1(cre)Zjh>/J | Vip, vasoactive intestinal polypeptide | Cre recombinase activity has been reported in some GABAergic interneurons |  |
| 009107 | B6.Cg-Tg(Wnt1-cre)11Rth Tg(Wnt1-GAL4)11Rth/J | Wnt1, wingless-related MMTV integration site 1 (mouse | Cre recombinase activity is expected in embryonic neural tube, midbrain, dorsal and ventral midlines of the midbrain and caudal diencephalon, the mid-hindbrain junction and dorsal spinal cord |  |
Facebase Tools Cre Strains: | ||||
| Stock number(links to data sheet) | Strain name (links to expression data) |
Promoter (species) | Expected site of expression | Expression data thumbnail |
| 018151 | C57BL/6N-Krt17<tm1(cre,Cerulean)Murr>/GrsrJ | Krt17, keratin 17 (mouse) | Cre recombinase expression is driven by the endogenous keratin 17 (Krt17) promoter/enhancer elements |  |
| 009388 | B6;129S1-Osr2<tm2(cre)Jian>/J | Osr2, odd-skipped related 2 (Drosophila), mouse, laboratory | Cre recombinase activity is reported in developing palate and urogenital tract |  |
| 018791 | C57BL/6J-Tg(Trp63,-cre,-Cerulean)3Grsr/GrsrJ | Trp63, transformation related protein 63 (mouse) | Cre recombinase expression is driven by Trp63 promoter/enhancer elements |  |
| 018792 | C57BL/6J-Tg(Trp63,-cre,-Cerulean)4Grsr/GrsrJ | Trp63, transformation related protein 63 (mouse) | Cre recombinase expression is driven by Trp63 promoter/enhancer elements |  |
| 005584 | B6.Cg-Tg(Prrx1-cre)1Cjt/J | Prrx1, paired related homeobox 1 (rat) | Cre recombinase activity is expected in early limb bud mesenchyme and in a subset of craniofacial mesenchyme, along with limited female germline expression |  |
| 018754 | C57BL/6J-Tg(Tbx22,-cre,-mCherry)1Grsr/GrsrJ | Tbx22, T-box transcription factor 22 (mouse) | Cre recombinase expression is driven by Tbx22 promoter/enhancer elements |  |
| 012719 | STOCK Tgfb3<tm1(cre)Vk/J |
Tgfb3, transforming growth factor, beta 3 (mouse) |
Cre recombinase activity is expected in the heart, pharyngeal arches, otic vesicle, mid brain, limb buds, midline palatal epithelium, and whisker follicles during embryo and fetus development |  |
| 009107 | B6.Cg-Tg(Wnt1-GAL4)11Rth Tg(Wnt1-Cre)11Rth |
Wnt1, wingless-related MMTV integration site 1 (mouse) |
Cre recombinase activity is expected in embryonic neural tube, midbrain, caudal diencephalon, the mid-hindbrain junction, dorsal spinal cord, and neural crest cells |  |
Inducible Strains: | ||||
| Stock number(links to data sheet) | Strain name (links to expression data) |
Promoter (species) | Expected site of expression | Expression data thumbnail |
| 004682 | B6.Cg-Tg(CAG-cre/Esr1)5Amc/J | ACTB, actin, beta (chicken) | Tamoxifen-inducible Cre recombinase expression is expected in most tissue types |  |
| 006774 | FVB-Tg(Col2a1-cre/ERT)KA3Smac/J | Col2a1, collagen, type II, alpha 1 (mouse) | Tamoxifen-inducible cre expression is expected in cells of the chondrogenic lineage (cartilage) during embryogenesis and postnatally. |  |
| 010705 | B6(Cg)-Dlx5<tm1(cre/ERT2)Zjh>/J | Dlx5, distal-less homeobox 5 | Tamoxifen-inducible Cre recombinase activity is expected in the cortex |  |
| 005107 | STOCK Tg(KRT14-cre/ERT)20Efu/J | KRT14, keratin 14 (human) | Tamoxifen-inducible Cre recombinase expression is expected in keratinocytes |  |
| 008875 | B6.129P2-Lgr5<tm1(cre/ERT2)Cle>/J | Lgr5, leucine rich repeat containing G protein coupled receptor 5 | Tamoxifen-inducible Cre recombinase expression is expected in crypt base columnar cells in small intestine (stem cells of the small intestine) and colon |  |
| 005657 | B6.FVB(129)-Tg(Myh6-cre/Esr1)1Jmk/J | Myh6, myosin, heavy polypeptide 6,(mouse) | Tamoxifen-inducible Cre recombinase expression is expected in developing and adult heart |  |
| 005975 | B6.Cg-Tg(Plp1-cre/ERT)3Pop/J | Plp1, proteolipid protein (myelin) 1 (mouse) | Tamoxifen-inducible Cre recombinase expression is expected in oligodendrocytes and Schwann cells |  |
| 008085 | B6.Cg-Tg(UBC-cre/ERT2)1Ejb/J | UBC, ubiquitin C (human) | Tamoxifen-inducible Cre recombinase expression is expected in all tissue types |  |
| 009103 | B6;C3-Tg(Wfs1-cre/ERT2)3Aibs/J | Wfs1, Wolfram syndrome 1 homolog (human) | Tamoxifen-inducible Cre recombinase expression is directed to cortex, hippocampus, striatum, thalamus and cerebellum only following tamoxifen administration |  |